期刊
CELL CYCLE
卷 12, 期 22, 页码 3465-3470出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.26625
关键词
yeast; telomeres; homeostasis; genome stability; cancer; aging
类别
资金
- Israel Ministry of Science and Technology
- Israel Cancer Research Fund
- Israel Cancer Foundation
- Machiah foundation
- Safra Center for Bioinformatics
Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic chromosomes, thus protecting their stability and integrity. They play important roles in DNA replication and repair and are central to our understanding of aging and cancer development. In rapidly dividing cells, telomere length is maintained by the activity of telomerase. About 400 TLM (telomere length maintenance) genes have been identified in yeast, as participants of an intricate homeostasis network that keeps telomere length constant. Two papers have recently shown that despite this extremely complex control, telomere length can be manipulated by external stimuli. These results have profound implications for our understanding of cellular homeostatic systems in general and of telomere length maintenance in particular. In addition, they point to the possibility of developing aging and cancer therapies based on telomere length manipulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据