期刊
CELL CYCLE
卷 12, 期 19, 页码 3159-3164出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.26062
关键词
cyclin-dependent kinase; G2 checkpoint; cell cycle; DNA damage; MK 1775
类别
Wee1, a protein kinase, regulates the G(2) checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer. MK-1775, a selective and potent small-molecule inhibitor of wee1, is under clinical development as a potentiator of DNA damage caused by cytotoxic chemotherapies. We present a review of the role of wee1 in the cell cycle and DNA replication and summarize the clinical development to date of this novel class of anticancer agents.
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