期刊
FASEB JOURNAL
卷 17, 期 14, 页码 1986-1995出版社
WILEY
DOI: 10.1096/fj.03-0053rev
关键词
arachidonic acid; cancer; cyclooxygenase and lipoxygenase inhibitors; eicosanoids
Cyclooxygenase (COX) and lipoxygenase (LO) metabolic pathways are emerging as key regulators of cell proliferation and neo-angiogenesis. COX and LO inhibitors are being investigated as potential anticancer drugs and results from clinical trials seem to be encouraging. In this article we will review evidence of COX-2 and 5-LO involvement in cancer pathobiology, propose a model of integrated control of cell proliferation by these enzymes, and discuss the pharmacologic implications of this model. -Romano, M., Claria, J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy.
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