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TOR links starvation responses to telomere length maintenance

期刊

CELL CYCLE
卷 11, 期 12, 页码 2268-2271

出版社

TAYLOR & FRANCIS INC
DOI: 10.4161/cc.20401

关键词

TOR; starvation; telomeres; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Yku70; Wtm1; Yku80; Gln3

资金

  1. Association for International Cancer Research (AICR)
  2. Israel Cancer Research fund
  3. Israel Cancer Research Foundation

向作者/读者索取更多资源

Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.

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