期刊
CELL CYCLE
卷 11, 期 12, 页码 2268-2271出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.20401
关键词
TOR; starvation; telomeres; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Yku70; Wtm1; Yku80; Gln3
类别
资金
- Association for International Cancer Research (AICR)
- Israel Cancer Research fund
- Israel Cancer Research Foundation
Telomeres are nucleoprotein structures that protect the ends of eukaryotic chromosomes and play important roles in ensuring the genome's integrity. Telomere length is maintained by complex mechanisms that ensure length homeostasis. Recent work has linked telomere length maintenance to the Tor protein kinases, which are central regulators of cellular growth. Here we summarize these results, which suggest a link between nutrient availability, telomere length maintenance and chronological lifespan.
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