期刊
CELL CYCLE
卷 11, 期 9, 页码 1757-1764出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.19883
关键词
c-Myc; transcription; max; gene regulation; chromatin; retinoic acid; RAR; leukemia
类别
资金
- Spanish Ministerio de Educacion y Ciencia [BFU2010-18692]
- AGAUR
- Fundacio La Marato
- ICREA Funding Source: Custom
The transcription factor c-Myc strongly stimulates cell proliferation but also regulates apoptosis, senescence, cell competition and cell differentiation, and its elevated activity is a hallmark for human tumorigenesis. c-Myc induces transcription by forming heterodimers with Max and then directly binding DNA at E-box sequences. Conversely, transcription repression depends primarily on the inhibitory interaction of c-Myc/Max with Miz-1 at DNA initiator elements. We recently described a distinct mechanism of c-Myc gene regulation, in which c-Myc interacts with the retinoic acid receptor alpha (RAR alpha) and is recruited to RAR DNA binding sequences (RAREs). In leukemia cells, this c-Myc/RAR alpha complex functions either as an activator or a repressor of RAR alpha-dependent targets through a phosphorylation switch. Unphosphorylated c-Myc interacts with RAR alpha to repress the expression of RAR targets required for differentiation, thereby aggravating leukemia malignancy. However, if c-Myc is phosphorylated by the kinase Pak2, the c-Myc/RAR alpha complex activates transcription of those same genes to stimulate differentiation, thus reducing tumor burden. Here, we discuss the role of c-Myc in balancing proliferation and differentiation and how modulating this previously unidentified c-Myc activity might provide alternative therapies against leukemia and possibly other types of tumors.
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