期刊
CELL CYCLE
卷 11, 期 17, 页码 3304-3311出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.21669
关键词
circadian; NF kappa B; Clock mutant; fibroblasts; BMAL1; Dbp; RelB; inflammation
类别
资金
- AIRC (Associazione Italiana per la Ricerca sul Cancro)
- Della Martin Foundation
- National Institute of Health
- Institut National de la Sante et de la Recherche Medicale
The circadian system controls a large array of physiological and metabolic functions. The molecular organization of the circadian clock is complex, involving various elements organized in feedback regulatory loops. Here we demonstrate that the RelB subunit of NF kappa B acts as a repressor of circadian transcription. RelB physically interacts with the circadian activator BMAL1 in the presence of CLOCK to repress circadian gene expression at the promoter of the clock-controlled gene Dbp. The repression is independent of the circadian negative regulator CRY. Notably, RelB(-/-) fibroblasts have profound alterations of circadian genes expression. These findings reveal a previously unforeseen function for RelB as an important regulator of the mammalian circadian system in fibroblasts.
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