相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Phase II trial of temsirolimus in patients with metastatic breast cancer
Gini F. Fleming et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
Targeting mTOR Pathways in Human Malignancies
Angelica Fasolo et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
The mTOR Signalling Pathway in Human Cancer
Helena Populo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Rapamycin Promotes Autophagy and Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice
Akira Sekiguchi et al.
JOURNAL OF NEUROTRAUMA (2012)
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
Vladimir N. Anisimov et al.
CELL CYCLE (2011)
mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency A roadmap from energy metabolism to stem cell renewal and aging
Javier A. Menendez et al.
CELL CYCLE (2011)
TOR in the immune system
Koichi Araki et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
mTOR signaling in disease
Eva Dazert et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
Emerging roles for mammalian target of rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
Nushmia Z. Khokhar et al.
CURRENT OPINION IN ONCOLOGY (2011)
TOR on the brain
Michael G. Garelick et al.
EXPERIMENTAL GERONTOLOGY (2011)
Differential effect of aging on axon sprouting and regenerative growth in spinal cord injury
Anne Jaerve et al.
EXPERIMENTAL NEUROLOGY (2011)
Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study
Marianne E. Pavel et al.
LANCET (2011)
Repertoire of microglial and macrophage responses after spinal cord injury
Samuel David et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Fighting neurodegeneration with rapamycin: mechanistic insights
Jordi Bove et al.
NATURE REVIEWS NEUROSCIENCE (2011)
PI3K/AKT/mTOR pathway in angiogenesis
Jayashree Karar et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)
Updates of mTOR Inhibitors
Hongyu Zhou et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al.
CELL METABOLISM (2010)
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau EFFECTS ON COGNITIVE IMPAIRMENTS
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2010)
PTEN deletion enhances the regenerative ability of adult corticospinal neurons
Kai Liu et al.
NATURE NEUROSCIENCE (2010)
mToR signaling and drug development in cancer
Janet Dancey
NATURE REVIEWS CLINICAL ONCOLOGY (2010)
ATP-MEDIATED PROTEIN KINASE B Akt/MAMMALIAN TARGET OF RAPAMYCIN mTOR/P70 RIBOSOMAL S6 PROTEIN p70S6 KINASE SIGNALING PATHWAY ACTIVATION PROMOTES IMPROVEMENT OF LOCOMOTOR FUNCTION AFTER SPINAL CORD INJURY IN RATS
L. Y. Hu et al.
NEUROSCIENCE (2010)
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-beta Levels in a Mouse Model of Alzheimer's Disease
Patricia Spilman et al.
PLOS ONE (2010)
Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
Tao Ma et al.
PLOS ONE (2010)
Validation of anti-aging drugs by treating age-related diseases
Mikhail V. Blagosklonny
AGING-US (2009)
Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
Cinzia Dello Russo et al.
BIOCHEMICAL PHARMACOLOGY (2009)
Rapamycin decelerates cellular senescence
Zoya N. Demidenko et al.
CELL CYCLE (2009)
mTOR: taking cues from the immune microenvironment
Greg M. Delgoffe et al.
IMMUNOLOGY (2009)
The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord
Simone Codeluppi et al.
JOURNAL OF NEUROSCIENCE (2009)
Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation
William A. Tyler et al.
JOURNAL OF NEUROSCIENCE (2009)
Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination
S. Priyadarshini Narayanan et al.
JOURNAL OF NEUROSCIENCE (2009)
Conversion from a Calcineurin Inhibitor to Everolimus Therapy in Maintenance Liver Transplant Recipients: A Prospective, Randomized, Multicenter Trial
Paolo De Simone et al.
LIVER TRANSPLANTATION (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Myelin pathogenesis and functional deficits following SCI are age-associated
Monica M. Siegenthaler et al.
EXPERIMENTAL NEUROLOGY (2008)
Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNFα-Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane
Adam R. Ferguson et al.
JOURNAL OF NEUROSCIENCE (2008)
Efficacy of everolimus in advanced renal cell carcinoma:: a double-blind, randomised, placebo-controlled phase III trial
Robert J. Motzer et al.
LANCET (2008)
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury
Silvia Carloni et al.
NEUROBIOLOGY OF DISEASE (2008)
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Tianhong Pan et al.
NEUROBIOLOGY OF DISEASE (2008)
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Kevin Kyungsuk Park et al.
SCIENCE (2008)
Changes in nitric oxide synthase expression in young and adult rats after spinal cord injury
J-Y Yang et al.
SPINAL CORD (2007)
Replacement of Calcineurin-inhibitors with Sirolimus as primary immunosuppression in stable cardiac transplant recipients
Eugenia Raichlin et al.
TRANSPLANTATION (2007)
Rapamycin is a neuroprotective treatment for traumatic brain injury
S. Erlich et al.
NEUROBIOLOGY OF DISEASE (2007)
Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved
Isabelle Pineau et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
Nitric oxide in the injured spinal cord: Synthases cross-talk, oxidative stress and inflammation
Alfredo Conti et al.
BRAIN RESEARCH REVIEWS (2007)
Hypoxia-induced iNOS expression in microglia is regulated by the P13-kinase/Akt/mTOR signaling pathway and activation of hypoxia inducible factor-1α
Dah-Yuu Lu et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes
Shakil A. Khan et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)
Rapamycin pre-treatment protects against apoptosis
B Ravikumar et al.
HUMAN MOLECULAR GENETICS (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
Increased oxidative-related mechanisms in the spinal cord injury in old rats
T Genovese et al.
NEUROSCIENCE LETTERS (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Spinal cord injury is accompanied by chronic progressive demyelination
MO Totoiu et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury
ND Vaziri et al.
BRAIN RESEARCH (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Locomotor recovery and mechanical hyperalgesia following spinal cord injury depend on age at time of injury in rat
YS Gwak et al.
NEUROSCIENCE LETTERS (2004)
Early expression and cellular localization of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-α in human traumatic spinal cord injury
LQ Yang et al.
SPINE (2004)
Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
J Widenfalk et al.
NEUROSCIENCE (2003)
Therapeutic strategies targeting caspase inhibition following spinal cord injury in rats
H Ozawa et al.
EXPERIMENTAL NEUROLOGY (2002)
Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
F Facchiano et al.
JOURNAL OF NEUROSURGERY (2002)
Intestinal transplantation before and after the introduction of sirolimus
TM Fishbein et al.
TRANSPLANTATION (2002)
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
M Guba et al.
NATURE MEDICINE (2002)
Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat
CE Hill et al.
EXPERIMENTAL NEUROLOGY (2001)
Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death
BA Citron et al.
EXPERIMENTAL NEUROLOGY (2000)
TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease
L Probert et al.
BRAIN (2000)
Review of current evidence for apoptosis after spinal cord injury
MS Beattie et al.
JOURNAL OF NEUROTRAUMA (2000)
Survival of motor neurons and expression of β-amyloid protein in the aged rat spinal cord
YY Xie et al.
NEUROREPORT (2000)