期刊
CELL CYCLE
卷 11, 期 11, 页码 2137-2145出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.20598
关键词
miR-145; N-RAS; VEGF-A; angiogenesis; breast cancer
类别
资金
- National Key Basic Research Program of China [2011CB504003]
- National Natural Science Foundation of China [81071642]
- State High Technology Developing Project [2008AA02Z115]
- National Science Foundation of China [30430240]
- Shanghai Metropolitan Fund for Research and Development [04DZ14005, 04JC14096]
- National Cancer Institute, NIH [CA109460]
MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.
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