期刊
CELL CYCLE
卷 11, 期 2, 页码 361-366出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.11.2.18794
关键词
microRNA; KRAS; 3'UTR; SNP; let-7; KRAS-variant
类别
资金
- Mary Kay Ash Foundation
The KRAS variant is a germline, single nucleotide polymorphism (SNP) within the 3'UTR of the KRAS gene predicted to disrupt a complementary binding site (LCS6) for the let-7 microRNA (miRNA). The KRAS variant is associated with increased risk of various cancers, including lung cancer, ovarian cancer and triple-negative breast cancer, and is associated with altered tumor biology in head and neck cancer, colon cancer and melanoma. To better understand the molecular pathways that may be regulated or affected by the presence of the KRAS variant allele in cancer cells, we examined its prevalence in the NCI-60 panel of cell lines and sought to identify common features of the cell lines that carry the variant allele. This study provides a step forward toward understanding the molecular and pathological significance of the KRAS variant.
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