期刊
CELL CYCLE
卷 10, 期 16, 页码 2647-2657出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.10.16.17194
关键词
EGFR; HER4; isoforms; alternative splicing; cancer; non-neoplastic diseases
类别
资金
- Academy of Finland
- Finnish Cancer Organizations
- Foundation for the Finnish Cancer Institute
- Sigrid Juselius Foundation
- Turku University Foundation
Alternative splicing is a central tool of evolution that significantly increases the size of transcriptomes and generates functional specification. Within the human ERBB receptor gene family, only ERBB4 is known to produce functionally distinct isoforms as a result of alternative splicing. While ErbB4 signaling has been demonstrated to regulate cellular processes involved in embryogenesis, carcinogenesis, and cardiovascular and psychiatric diseases, relatively little is known about the contribution of the individual isoforms in the different biological contexts. Here we review recent findings as well as provide novel data about the distribution and functions of the ERBB4 splice variants. These observations represent an example of how minor alterations in the transcripts of a single gene can result in even antagonistic cellular responses. The observations also underline the significance of understanding the unique functions of isoforms of a potential drug target gene.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据