期刊
CELL CYCLE
卷 10, 期 3, 页码 396-405出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.10.3.14709
关键词
winged helix DNA binding domain; forkhead transcription factor; FoxM1; embryonic development; cancer; cellular proliferation; cell cycle; transgenic mice
类别
资金
- American Cancer Society, Ohio Division
- Concern Foundation [84794]
- DOD [PC080478]
- NIH [R01 CA142724, R01 HL84151]
- American Cancer Society, National office [RSG-06-187-01]
FoxM1 transcription factor (previously called HFH-11B, Trident, FoxM1b, Win and MPP2) is expressed in actively dividing cells and critical for cell cycle progression. FoxM1 expression is induced in a variety of tissues during embryogenesis, and Foxm1(-/-) mice exhibit embryonic lethal phenotype due to multiple abnormalities in the liver, heart, lung and blood vessels. FoxM1 levels are dramatically decreased in adult tissues, but FoxM1 expression is re-activated during organ injury and numerous cancers. In this review, we discussed the role of FoxM1 in different cell lineages using recent data from transgenic mouse models with conditional gain-of-function and loss-of-function of FoxM1, as well as tissue samples from human patients. In addition, we provided experimental data showing additional sites of FoxM1 expression in the mouse embryo. Novel cell-autonomous roles of FoxM1 in embryonic development, organ injury and cancer formation in vivo were analyzed. Potential application of these findings for the diagnosis and treatment of human diseases were discussed.
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