期刊
CELL CYCLE
卷 10, 期 24, 页码 4272-4279出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.24.18567
关键词
p53; p63; p73; Mdm2; Mdm4; elephant shark
类别
资金
- Biomedical Research Council of A* STAR, Singapore
Analysis of the genome of the elephant shark (Callorhinchus milii), a member of the cartilaginous fishes (Class Chondrichthyes), reveals that it encodes all three members of the p53 gene family, p53, p63 and p73, each with clear homology to the equivalent gene in bony vertebrates (Class Osteichthyes). Thus, the gene duplication events that lead to the presence of three family members in the vertebrates dates to before the Silurian era. It also encodes Mdm2 and Mdm4 genes but does not encode the p19(Arf) gene. Detailed comparison of the amino acid sequences of these proteins in the vertebrates reveals that they are evolving at highly distinctive rates, and this variation occurs not only between the three family members but extends to distinct domains in each protein.
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