期刊
CELL CYCLE
卷 10, 期 10, 页码 1582-1589出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.10.15619
关键词
thrombopoietin; TPO; Mpl; hematopoietic stem cell; hematopoiesis; Jak2; MPLW515K; MPLW515L
类别
资金
- National Health and Medical Research Council
- National Institutes of Health [CA22556]
- Cancer Council, Victoria
Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte production but increasingly attention has turned to its role in maintaining hematopoietic stem cells (HSCs). HSCs are required to initiate the production of all mature hematopoietic cells, but this differentiation needs to be balanced against self-renewal and quiescence to maintain the stem cell pool throughout life. TPO has been shown to support HSC quiescence during adult hematopoiesis, with the loss of TPO signaling associated with bone marrow failure and thrombocytopenia. Recent studies have shown that constitutive activation mutations in Mpl contribute to myeloproliferative disease. In this review, we will discuss TPO signaling pathways, regulation of TPO levels and the role of TPO in normal hematopoiesis and during myeloproliferative disease.
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