期刊
CELL CYCLE
卷 10, 期 15, 页码 2423-2427出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.10.15.16869
关键词
induced pluripotent stem cells (iPSCs); hepatic differentiation; liver engraftment; disease modeling; drug testing; alpha-1 antitrypsin; liver cirrhosis; hepatocellular carcinoma; cell therapy
类别
资金
- NIH [109577]
- MSCRF [108563, 106408, 108592]
Human induced pluripotent stem cells (iPSCs) are potential renewable sources of hepatocytes for drug development and cell therapy. Differentiation of human iPSCs into different developmental stages of hepatic cells has been achieved and improved during the last several years. We have recently demonstrated the liver engraftment and regenerative capabilities of human iPSC-derived multistage hepatic cells in vivo. Here we describe the in vitro and in vivo activities of hepatic cells derived from patient-specific iPSCs, including multiple lines established from either inherited or acquired liver diseases, and discuss basic and clinical applications of these cells for disease modeling, drug screening and discovery, gene therapy and cell replacement therapy.
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