期刊
CELL CYCLE
卷 9, 期 11, 页码 2124-2129出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.11.11843
关键词
miR-31; metastasis; breast cancer; microRNA; invasion-metastasis cascade; microRNA sponge; integrin alpha 5; radixin; RhoA; p53; stem cell
类别
资金
- NIH [RO1-CA078461]
- MIT Ludwig Center for Molecular Oncology
- U.S. Department of Defense
- Breast Cancer Research Foundation
- NATIONAL CANCER INSTITUTE [R01CA078461] Funding Source: NIH RePORTER
MicroRNAs constitute a family of pleiotropically acting short regulatory RNAs. Increasingly, specific microRNAs have been implicated as key modulators of a variety of normal physiologic processes; moreover, the aberrant activity of certain microRNAs has been linked to the pathogenesis of multiple diseases. The microRNA miR-31 has been identified as a crucial overseer of several normal and diseased phenotypes. Here, we describe current knowledge regarding the functions of miR-31, with an emphasis placed upon the role of this microRNA in neoplastic development and tumor metastasis. Additionally, we highlight a number of recent reports concerning the contributions of miR-31 to other pathological states, the role of this microRNA in normal physiology, and the upstream mechanisms by which miR-31 expression levels are regulated. Assessed collectively, existing evidence suggests that miR-31 concomitantly regulates a number of essential signaling pathways in mammalian cells. For these reasons, further elucidation of the biological actions of miR-31 may prove significant for the prognosis and remediation of various pathological states.
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