期刊
CELL CYCLE
卷 9, 期 24, 页码 4824-4835出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.24.14322
关键词
interleukin-4; tumor-associated macrophage; tumor microenvironment; cytokines; cathepsin proteases
类别
资金
- National Cancer Institute
- Breast Cancer Research Foundation
- Geoffrey Beene Foundation
- Frank L. Horsfall Jr. Fellowship
- Taiwan Merit Scholarship
Although macrophages were originally recognized as major immune effector cells, it is now appreciated that they also play many important roles in the maintenance of tissue homeostasis, and are involved in a variety of pathological conditions including cancer. Several studies have demonstrated the contributions of tumor-associated macrophages (TAMs) to tumor initiation, progression and metastasis. However, the detailed mechanisms underlying how TAMs differ molecularly from their normal counterparts and how the conversion to TAMs occurs have only just begun to be understood. TAMs have been proposed to exhibit phenotypes of 'alternatively activated' macrophages, though there has been limited evidence directly linking the phenotypes of TAMs to the alternative activation of macrophages. This review will focus on IL-4, the prototypic cytokine that induces the alternative activation of macrophages, and review current knowledge regarding the contributions of IL-4 to the phenotypes of TAMs and its effects on tumorigenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据