期刊
CELL CYCLE
卷 9, 期 6, 页码 1065-1071出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.6.10982
关键词
TNF; RIP; IAP; TRAF; apoptosis; necrosis; NF kappa B; ubiquitin
类别
资金
- NIH [AI052417]
- Crohn's and Colitis Foundation of America
The kinase RIP1 wears a coat of many colors during TNF receptor signaling and can regulate both activation of prosurvival NF kappa B and programmed cell death pathways. In this review, we outline how coating RIP1 with K63-linked ubiquitin chains forms a protective layer that prevents RIP1 from binding apoptotic regulators and serves as an early guard against cell death. Further on, binding of NF kappa B signaling components to the ubiquitin coat of RIP1 activates long-term pro-survival signaling and forms a more impenetrable suit of armor against cell death. If RIP1 is not decorated with ubiquitin chains it becomes an unstoppable harbinger of bad news: programmed cell death.
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