Big bang nucleosynthesis (BBN) has increasingly become the tool of choice for investigating the permitted variation of fundamental constants during the earliest epochs of the Universe. Here we present a BBN calculation that has been modified to permit changes in the QCD scale, Lambda(QCD). The primary effects of changing the QCD scale upon BBN are through the deuteron binding energy B-D and the neutron-proton mass difference deltam(np), which both play crucial roles in determining the primordial abundances. In this paper we show how a simplified BBN calculation allows us to restrict the nuclear data we need to just B-D and deltam(np) yet still gives useful results so that any variation in Lambda(QCD) may be constrained via the corresponding shifts in B-D and deltam(np) by using the current estimates of the primordial deuterium abundance and helium mass fraction. The simplification predicts the helium-4 and deuterium abundances to within 1% and 50%, respectively, when compared with the results of a standard BBN code. But Lambda(QCD) also affects much of the remaining required nuclear input so this method introduces a systematic error into the calculation and we find a degeneracy between B-D and deltam(np). We show how increased understanding of the relationship of the pion mass and/or B-D to other nuclear parameters, such as the binding energy of tritium and the cross section of T+D-->He-4+n, would yield constraints upon any change in B-D and deltam(np) at the 10% level.
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