期刊
CELL CYCLE
卷 9, 期 22, 页码 4469-4473出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.22.13684
关键词
centrosome; cancer; kinetochore; mitotic checkpoint; p53; p21(WAF); senescence
类别
资金
- DFG [SFB 728]
- research commission of the medical faculty of the Heinrich-Heine-University
- NRW Research School
Altered cell division is associated with overproliferation and tumorigenesis, however, mitotic aberrations can also trigger antiproliferative responses leading to postmitotic cell cycle exit. Here, we focus on the role of the centrosome and in particular of centrosomal TACC (transforming acidic coiled coil) proteins in tumorigenesis and cellular senescence. We have compiled recent evidence that inhibition or depletion of various mitotic proteins which take over key roles in centrosome and kinetochore integrity and mitotic checkpoint function is sufficient to activate a p53-p21(WAF) driven premature senescence phenotype. These findings have direct implications for proliferative tissue homeostasis as well as for cellular and organismal aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据