期刊
JOURNAL OF NEUROCHEMISTRY
卷 87, 期 6, 页码 1313-1320出版社
WILEY
DOI: 10.1046/j.1471-4159.2003.02116.x
关键词
apoptosis; circadian rhythms; CREB; gene expression; learning; memory; neurodegeneration
The acronym ICER (inducible cAMP early repressor) refers to a group of four proteins produced from the CREM/ICER gene due to use of an internal promoter (P2) placed in an intron of the CREM (cAMP responsive element modulator) gene. The ICER proteins contain DNA binding/leucine zipper domains that make them endogenous inhibitors of transcription driven by CREB (cAMP responsive element binding protein) and its cognates, CREM and ATF-1 (activating transcription factor-1). ICER expression is inducible in the brain and in neuronal culture by a variety of stimuli. As a CREB antagonist, ICER appears to be of pivotal importance in neuronal plasticity and programmed cell death.
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