期刊
CELL CYCLE
卷 9, 期 22, 页码 4487-4491出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.9.22.14047
关键词
DNA replication; cell cycle control; centrosome; MCM; ORC
类别
资金
- Canadian Institutes of Health Research (CIHR) [79473]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [203528-2008]
Genome replication is the most fundamental element of the continuity of life. In eukaryotes, DNA replication is regulated by an elegant network of many different protein factors to ensure the timely and accurate copying of their entire genome once per cell cycle. The replication factors include the origin recognition complex (ORC), minichromosome maintenance (MCM) proteins, Cdt1, Cdc6, Cdc7, Cdc45 and geminin. All of these proteins are involved in the regulation of DNA replication at the initiation step. Interestingly, recent studies have shown that some of these replication proteins also localize to the centrosome, often throughout the entire cell cycle. These centrosomally localized replication proteins appear to play essential roles in the regulation of centrosome biogenesis, suggesting that genome replication and segregation are regulated interdependently. In this review, we summarize and discuss the inter-dependent regulation played by some of the replication proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据