期刊
CELL CYCLE
卷 8, 期 12, 页码 1966-1967出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.12.8708
关键词
FoxM1; autoregulation; transcription; thiazole antibiotics; FoxM1 inhibitors
类别
资金
- NCI NIH HHS [1 R01 CA1294414-01A1, 1 R21 CA134615-01] Funding Source: Medline
Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.
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