期刊
CELL CYCLE
卷 8, 期 17, 页码 2708-2710出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.17.9457
关键词
survivin; PTEN; tumor suppressor; apoptosis; gene regulation
类别
资金
- NIH [CA78810, CA118005, CA90917]
Despite the constant exposure to genomic insults that may lead to malignancy, cancer is surprisingly a relatively rare occurrence, and this is largely credited to an elaborate network of endogenous tumor suppression. Many effectors of tumor suppression have been identified, and their functions when activated in damaged cells have in large part been elucidated. What is less clear is whether there are common target gene(s) of tumor suppression, whose expression must be ablated in order to block transformation and preserve cellular homeostasis. Fresh experimental evidence suggests that silencing of the mitotic regulator and cell death inhibitor, survivin, is a universal requirement for successful tumor suppression in humans.
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