期刊
CELL CYCLE
卷 8, 期 20, 页码 3262-3266出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.20.9690
关键词
taxol; paclitaxel; chromosomal instability; spindle; segregation errors; aneuploidy; mitosis; centrosome
类别
资金
- Cancer Research UK
- Medical Research Council
Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.
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