期刊
BIOLOGY OF REPRODUCTION
卷 69, 期 5, 页码 1615-1625出版社
SOC STUDY REPRODUCTION
DOI: 10.1095/biolreprod.103.019877
关键词
gametogenesis; meiosis; oocyte development; spermatid; spermatogenesis
资金
- NCI NIH HHS [CA 34196] Funding Source: Medline
- NICHD NIH HHS [P01 HD042137] Funding Source: Medline
- NIGMS NIH HHS [GM 66650-01, GM 64275-01A, GM 45415] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD042137] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA034196] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM066650, R01GM045415, F32GM064275] Funding Source: NIH RePORTER
The genetic control of mammalian gametogenesis is inadequately characterized because of a lack of mutations causing infertility. To further the discovery of genes required for mammalian gametogenesis, phenotype-driven screens were performed in mice using random chemical mutagenesis of whole animals and embryonic stem cells. Eleven initial mutations are reported here that affect proliferation of germ cells, meiosis, spermiogenesis, and spermiation. Nine of the mutations have been mapped genetically. These preliminary studies provide baselines for estimating the number of genes required for gametogenesis and offer guidance in conducting new genetic screens that will accelerate and optimize mutant discovery. This report demonstrates the efficacy and expediency of mutagenesis to identify new genes required for mammalian gamete development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据