期刊
CELL CYCLE
卷 8, 期 20, 页码 3297-3302出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.20.9761
关键词
cancer stem cell; breast cancer; retinoid signaling; ALDH; tumor-sphere; gene set enrichment analysis
类别
资金
- Ligue Nationale Contre le Cancer (Label DB)
- Institut National du Cancer [PL2008]
The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic approaches to target the CSC population. Characterization of the pathways that regulate CSCs activity will facilitate the development of targeted therapies. We recently reported that the enzymatic activity of ALDH1, as measured by the ALDELFUOR assay, can be utilized to isolate normal and malignant breast stem cells in both primary tumors and cell lines. In this study, utilizing a tumorsphere assay, we have demonstrated the role of retinoid signaling in the regulation of breast CSCs self-renewal and differentiation. Utilizing the gene set enrichment analysis (GSEA) algorithm we identified gene sets and pathways associated with retinoid signaling. These pathways regulate breast CSCs biology and their inhibition may provide novel therapeutic approaches to target breast CSCs.
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