期刊
CELL CYCLE
卷 8, 期 1, 页码 49-57出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.8.1.7259
关键词
post-translational modifications-PTM; domain; tumor suppression; transformation; transcription; yap; hippo pathway
类别
资金
- EC FP6
- Active p53 [LSHC-CT-2004-503576]
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
Yap is a small protein that binds to many transcription factors and modulates their activity. Yap was described to increase the ability of p73 in inducing apoptosis as a consequence of damage to the DNA, and therefore its activity was thought to favor tumor-suppression. However, other studies have recently shown a role for Yap in cell differentiation, cell transformation and in the regulation of organ size. It has been demonstrated that the Drosophila Hippo pathway has a mammalian equivalent, and that Yap is part of this pathway, where it might stimulate proliferation. In light of these new findings we ought to re-consider the role of Yap, which seems to be in service of several masters, and whose regulation-likely at the level of PTM-and cellular context might have a pivotal role in the choice of its partners and consequently on the final outcome.
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