期刊
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
卷 27, 期 1, 页码 1-6出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jes.2015.36
关键词
left-censored data; detection limit; censored bioassay data; intake estimation
In retrospective epidemiological studies of large cohorts of workers exposed to radioactive materials, it is often necessary to analyze large numbers of bioassay data sets containing censored values, or values recorded as less than a detection limit. Censored bioassay data create problems for all bioassay analysis methods, including analytical techniques based on least-squares regression to estimate intakes. A method is presented here that uses a simple empirically-derived equation for imputing replacement values for urine uranium concentration results reported as zero or less than a detection limit, that produces minimal bias in intakes estimated using least-square regression methods with the assumption of lognormally distributed measurement errors.
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