期刊
CELL CYCLE
卷 7, 期 21, 页码 3294-3301出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.21.6927
关键词
SINES; Alu elements; RNA editing; gene regulation; nuclear retention
类别
资金
- NIH [CA04382]
The Alu elements are conserved similar to 300 nucleotide long repeat sequences that belong to the SINE family of retrotransposons found abundantly in primate genomes. Although the vast majority of Alu elements appear to be genetically inert, it has been tempting to consider the great majority of them as junk DNA. However, a growing line of evidence suggests that transcribed Alu RNAs are in fact functionally involved in a number of diverse biological processes. Pairs of inverted Alu repeats in RNA can form duplex structures that lead to A-to-I editing by the ADAR enzymes. In this review we discuss the possible biological effects of Alu editing, with particular focus on the regulation of gene expression by inverted Alu repeats in the 3'-UTR regions of mRNAs.
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