期刊
CELL CYCLE
卷 7, 期 3, 页码 277-282出版社
LANDES BIOSCIENCE
DOI: 10.4161/cc.7.3.5328
关键词
p53 signalling; p21; pRb; p84N5; cell death
类别
资金
- Medical Research Council [MC_U117573807] Funding Source: Medline
- MRC [MC_U117573807] Funding Source: UKRI
- Medical Research Council [MC_U117573807] Funding Source: researchfish
There have been innumerate demonstrations of p53' s activity as a tumour suppressor protein with the ability to stimulate cell signalling that can lead to cell cycle arrest and cell death in the event of DNA damage. Despite the solid body of evidence to support these properties of p53, reports have emerged that suggest a role for p53 in protecting cells from cell death. Our recent report highlighted a mechanism by which p53 activity can promote cell survival in the event of DNA damage. Here we present the various mechanisms that are activated by p53 signalling that can confer protection to cells with damaged DNA and emphasise the practical and clinical implications of a more balanced and context-dependent understanding of p53' s pro-apoptotic and pro-survival activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据