期刊
CELL CYCLE
卷 7, 期 22, 页码 3509-3513出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.22.6978
关键词
cell cycle machinery; spermatogenesis; germ cell differentiation; meiosis; male germ cell stem cells; mitosis; cyclin-dependent kinases; apoptosis
类别
资金
- NIH [HD034915]
- Indo-US Program on Contraception and Reproductive Health
The specialized cell cycles that characterize various aspects of the differentiation of germ cells provide a unique opportunity to understand heretofore elusive aspects of the in vivo function of cell cycle regulators. Key components of the cell cycle machinery are the regulatory sub-units, the cyclins, and their catalytic partners, the cyclin-dependent kinases. Some of the cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions, predictions that are being explored by targeted mutagenesis in mouse models. A novel, meiosis-specific function has been shown for one of the A-type cyclins, cyclin A1. Embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1, while yet other cyclins, although expressed at specific stages of germ cell development, may have less essential function in the male germline.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据