期刊
CELL CYCLE
卷 7, 期 21, 页码 3440-3447出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.21.6995
关键词
mutant p53; p73; short peptides; DNA damage; apoptosis
类别
资金
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
Many in vitro and in vivo evidence have shown that the status of p53 is a key determinant in the response of tumor cells to anticancer treatment. Here we provide evidence that peptide-mediated targeting of the protein complex mutantp53/p73 enhances the response of mutant p53 tumor cells to commonly used anticancer drugs. Indeed, we show that the disruption of the protein complex mutantp53/p73 and the consequent restoration of p73 transcriptional effects, through the activity of short interfering peptides, render mutant p53 cells more prone to the killing of adriamycin and cisplatin. Of note, the activity of the short interfering peptides is mutant p53 specific and causes no effects on wt-p53 and p53 null cells. Our findings highlight the protein complex mutantp53/p73 as a molecular target, whose successful overriding through the selective activity of small interfering peptides, might contribute to the optimization of mutant p53 tumor treatments.
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