期刊
JOURNAL OF IMMUNOLOGY
卷 170, 期 1, 页码 147-152出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.1.147
关键词
-
类别
资金
- NIAID NIH HHS [AI30048] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [Z01BC009405] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI030048, R37AI030048] Funding Source: NIH RePORTER
Acute viral infections induce extensive proliferation and differentiation of virus-specific CD8(+) T cells. One mechanism reported to regulate the proliferative capacity of activated lymphocytes is mediated by the effect of telomerase in maintaining the length of telomeres in proliferating cells. We examined the regulation of telomerase activity and telomere length in naive CD8(+) T cells and in virus-specific CD8(+) T cells isolated from mice infected with lymphocytic choriomeningitis virus. These studies reveal that, compared with naive CD8(+) T cells, which express little or no telomerase activity, Ag-specific effector and long-lived memory CD8(+) T cells express high levels of telomerase activity. Despite the extensive clonal expansion that occurs during acute lymphocytic choriomeningitis virus infection, telomere length is maintained in both effector and memory CD8(+) T cells. These results suggest that induction of telomerase activity in Ag-specific effector and memory CD8(+) T cells is important for the extensive clonal expansion of both primary and secondary effector cells and for the maintenance and longevity of the memory CD8(+) T cell population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据