期刊
CELL CYCLE
卷 7, 期 5, 页码 602-607出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.7.5.5522
关键词
RNAi; RNA; epigenetics; gene silencing; transcription; small RNAs
类别
资金
- NHLBI NIH HHS [R01 HL083473, R01 HL083473-01A1] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL083473] Funding Source: NIH RePORTER
The roles that RNA molecules play in the regulation of gene expression have only recently begun to come to light. Recent work in this area has uncovered several complex, RNA-mediated networks of gene regulation in eukaryotic systems. One newly discovered mechanism of RNA mediated gene regulation takes place at the level of transcription. In yeast, plant and mammalian systems, small RNAs targeted to gene promoters can result in a repression of transcription. Small RNA mediated transcriptional silencing has been shown to be operative by changes in chromatin structure at the targeted promoter. Specifically, silencing has been observed to correlate with decreases in certain active-state histone modifications, increases in certain silent-state histone modifications, and in some instances, DNA methylation at the targeted promoter. These epigenetic remodeling events represent a more stable, heritable form of gene regulation as opposed to the transitory, post-transcriptional regulation observed in traditional RNAi-mechanisms. Several recent findings have shed light on this newly discovered link between small RNA molecules and epigenetic regulatory machinery, notably in human cells.
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