期刊
CELL COMMUNICATION AND ADHESION
卷 21, 期 3, 页码 149-159出版社
INFORMA HEALTHCARE
DOI: 10.3109/15419061.2014.905928
关键词
cell junction; cardiac conduction system; desmosome; fascia adherens junction; gap junction; intercalated disc; cardiac muscle; heart; heart disease; anchoring junction
资金
- NHLBI-Graduate Research Assistant Diversity Supplement [NIH 3R01HL095780-01S2]
- NIH F31 Ruth L. Kirschstein National Research Service Award Graduate Fellowship [1F31HL120611-01]
- National Institute of Health [NIH 1R01HL095780-01]
- California Institute of Regenerative Medicine [CIRM RB3-05103]
- Saving tiny Heart Society grants
Anchoring cell junctions are integral in maintaining electro-mechanical coupling of ventricular working cardiomyocytes; however, their role in cardiomyocytes of the cardiac conduction system (CCS) remains less clear. Recent studies in genetic mouse models and humans highlight the appearance of these cell junctions alongside gap junctions in the CCS and also show that defects in these structures and their components are associated with conduction impairments in the CCS. Here we outline current evidence supporting an integral relationship between anchoring and gap junctions in the CCS. Specifically we focus on (1) molecular and ultrastructural evidence for cell-cell junctions in specialized cardiomyocytes of the CCS, (2) genetic mouse models specifically targeting cell-cell junction components in the heart which exhibit CCS conduction defects and (3) human clinical studies from patients with cell-cell junction-based diseases that exhibit CCS electrophysiological defects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据