期刊
CELL COMMUNICATION AND ADHESION
卷 15, 期 4, 页码 333-349出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15419060802440377
关键词
adherens junction; catenin; confluence; VE-cadherin
资金
- National Institutes of Health [HL-77870, HL-68079, AR-050501]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL077870, R01HL068079] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR050501] Funding Source: NIH RePORTER
Endothelial cells (ECs) express VE-cadherin and N-cadherin, and recent data suggest that VE-cadherin levels are dependent on N-cadherin expression. While investigating changes in N-cadherin levels during endothelial monolayer maturation, the authors found that VE-cadherin levels are maintained in ECs despite a decrease in N-cadherin, suggesting that VE-cadherin levels may not depend on N-cadherin. Knockdown of N-cadherin did not affect VE-cadherin levels in ECs with low endogenous N-cadherin expression. Surprisingly, however, knockdown of N-cadherin in ECs with high endogenous N-cadherin expression increased VE-cadherin levels, suggesting an inverse relationship between the two. This was further supported by a decrease in VE-cadherin following overexpression of N-cadherin. Experiments in which p120, a catenin that binds N- and VE-cadherin, was knocked down or overexpressed indicate that these two cadherins compete for p120. These data demonstrate that VE-cadherin levels are not directly related to N-cadherin levels but may be inversely related due to competition for p120.
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