期刊
JOURNAL OF VIROLOGY
卷 77, 期 2, 页码 1589-1594出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.77.2.1589-1594.2003
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Human immunodeficiency virus type I Nef down-regulates human leukocyte antigen class I (HLA-I) in T lymphocytes, and the down-regulation involves the Nef proline-rich domain (PRD) containing four prolines at positions 69, 72, 75, and 78. We used a Sendai virus vector with nef and examined regulation by Nef of HLA-1 and CD4 in suspension cultures of cells such as T lymphocytes. Analyses of a series of PRD substitution mutants indicated that, because the substitution of Pro78 with Ala abolished down-regulation of HLA-I but not of CD4, Pro78 is important for HLA-1 down-regulation in T lymphocytes.
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