期刊
CLINICAL INFECTIOUS DISEASES
卷 37, 期 9, 页码 1178-1182出版社
UNIV CHICAGO PRESS
DOI: 10.1086/378742
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We initiated a prospective trial of an intermittent clarithromycin-containing regimen for the treatment of patients with Mycobacterium kansasii lung disease. Eighteen patients (10 men and 8 women) with M. kansasii lung disease received a regimen consisting of 500-1000 mg of clarithromycin, 25 mg/kg ethambutol, and 600 mg of rifampin 3 times per week. The primary treatment end point was a 12-month period during which sputum cultures were sterile while the patient was receiving therapy. Four male patients were lost to follow-up, but all of the remaining patients successfully completed therapy without significant drug-related adverse events. The mean time (+/- standard deviation [SD]) to sputum conversion was months, and the 1.0 +/- 0.9 mean duration (+/-SD) of therapy was months. No patient who successfully completed therapy had 13.4 +/- 0.9 relapsed after a mean (+/-SD) of months. Clarithromycin- and rifampin-containing regimens offer 46 +/- 8.0 the possibility of effective short-course and intermittent treatment of M. kansasii lung disease.
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