期刊
CELL CALCIUM
卷 55, 期 1, 页码 24-37出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2013.10.006
关键词
Failed fertilization; Oocyte activation; ICSI; PLC zeta; Assisted oocyte activation; Sperm cytosolic factor; Calcium influx
类别
资金
- Clinical and Translational Science Center at Weill Cornell Medical College [ULI RR024996]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000457] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024996] Funding Source: NIH RePORTER
Since the establishment of in vitro fertilization, it became evident that almost half of the couples failed to achieve fertilization and this phenomenon was attributed to a male gamete dysfunction. The adoption of assisted fertilization techniques particularly ICSI has been able to alleviate male factor infertility by granting the consistent ability of a viable spermatozoon to activate an oocyte. Single sperm injection, by pinpointing the beginning of fertilization, has been an invaluable tool in clarifying the different aspects of early fertilization and syngamy. However, even with ICSI some couples fail to fertilize due to ooplasmic dysmaturity in relation to the achieved nuclear maturation marked by the extrusion of the first polar body. More uncommon are cases where the spermatozoa partially or completely lack the specific oocyte activating factor. In this work, we review the most relevant aspects of fertilization and its failure through assisted reproductive technologies. Attempts at diagnosing and treating clinical fertilization failure are described. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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