期刊
CELL CALCIUM
卷 56, 期 5, 页码 340-361出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2014.09.001
关键词
Calcium signaling; beta-Cells; Diabetes
类别
资金
- Fonds de la Recherche Scientifique (Brussels)
- ARC from the General Direction of Scientific Research of the French Community of Belgium [13/18-051]
- Inter-university Poles of Attraction Programme from the Belgian Science Policy [PAI 6/40]
- Wellcome Trust [WT098424AIA]
- MRC [MR/J0003042/1]
- Biological and Biotechnology Research Council (BBSRC) [BB/J015873/1]
- Diabetes UK [11/0004210]
- Royal Society
- Biotechnology and Biological Sciences Research Council [BB/J015873/1] Funding Source: researchfish
- BBSRC [BB/J015873/1] Funding Source: UKRI
Changes in cytosolic free Ca2+ concentration ([Ca2+](c)) play a crucial role in the control of insulin secretion from the electrically excitable pancreatic beta-cell. Secretion is controlled by the finely tuned balance between Ca2+ influx (mainly through voltage-dependent Ca2+ channels, but also through voltage-independent Ca2+ channels like store-operated channels) and efflux pathways. Changes in [Ca2+], directly affect [Ca2+] in various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi apparatus, secretory granules and lysosomes, as imaged using recombinant targeted probes. Because most of these organelles have specific Ca2+ influx and efflux pathways, they mutually influence free [Ca2+] in the others. In this article, we review the mechanisms of control of [Ca2+] in various compartments and particularly the cytosol, the endoplasmic reticulum ([Ca2+](ER)), acidic stores and mitochondrial matrix ([Ca2+](mito)), focusing chiefly on the most important physiological stimulus of beta-cells, glucose. We also briefly review some alterations of beta-cell Ca2+ homeostasis in Type 2 diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据