期刊
CELL CALCIUM
卷 53, 期 4, 页码 256-263出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2012.12.006
关键词
Calcium; Neuron; Astrocyte; Glucococorticoid; Corticosterone; Dexamethasone; Glutamate
类别
资金
- Thailand Research Fund (TRF)-Royal Golden Jubilee Ph.D. Program
- Mahidol University
- MRC [MC_G1000735] Funding Source: UKRI
- Medical Research Council [MC_G1000735] Funding Source: researchfish
- Parkinson's UK [F-0806] Funding Source: researchfish
Glucocorticoids are steroid hormones which act through the glucocorticoid receptor. They regulate a wide variety of biological processes. Two glucocorticoids, the naturally occurring corticosterone and chemically produced dexamethasone, have been used to investigate the effect of glucocorticoids on Ca2+-signalling in cortical co-cultures of neurons and astrocytes. Dexamethasone and to a lesser degree corticosterone both induced a decrease in cytosolic Ca2+ concentration in neurons and astrocytes. The effect of both compounds can be blocked by inhibition of the plasmamembrane ATPase, calmodulin and by application of a glucocorticoid receptor antagonist, while inhibition of NMDA receptors or the endoplasmic reticulum calcium pump had no effect. Glucocorticoid treatment further protects against detrimental calcium signalling and cell death by modulating the delayed calcium deregulation in response to glutamate toxicity. At the concentrations used dexamethasone and corticosterone did not show cell toxicity of their own. Thus, these results indicate that dexamethasone and corticosterone might be used for protection of the cells from calcium overload. (c) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据