期刊
CELL CALCIUM
卷 52, 期 3-4, 页码 296-302出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2012.04.010
关键词
Lung; Ca2+; Alveolus; Epithelium; Surfactant; Exocytosis; Secretion; Type II cell; Pneumocyte; Purinergic; Purinoceptor; P2Y2; P2X4; Cell stretch; Mechanotransduction; Air-liquid interface; STIM1; Orai1; Capacitative Ca2+ entry; TRIC B; TRPV2; Actin; FACE; Fusion-activated Ca2+ entry; SLO; Streptolysin
类别
资金
- DFG [DI 1402/3-1]
- BIU center UIm [D.5006]
- Austrian Science Fund (FWF) [P 20472] Funding Source: researchfish
The type II cell of the pulmonary alveolus is a polarized epithelial cell that secretes surfactant into the alveolar space by regulated exocytosis of lamellar bodies (LBs). This process consists of multiple sequential steps and is correlated to elevations of the cytoplasmic Ca2+ concentration ([Ca2+](c)) required for extended periods of secretory activity. Both chemical (purinergic) and mechanical (cell stretch or exposure to an air-liquid interface) stimuli give rise to complex Ca2+ signals (such as Ca2+ peaks, spikes and plateaus) that differ in shape, origin and spatio-temporal behavior. This review summarizes current knowledge about Ca2+ channels, including vesicular P2X4 purinoceptors, in type II cells and associated signaling cascades within the alveolar microenvironment, and relates stimulus-dependent activation of these pathways with distinct stages of surfactant secretion, including pre- and postfusion stages of LB exocytosis. (C) 2012 Elsevier Ltd. All rights reserved.
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