期刊
CELL CALCIUM
卷 52, 期 3-4, 页码 289-295出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2012.03.005
关键词
Exocytosis; C. elegans; Presynaptic; Vesicle fusion; SNARE; Munc18
类别
The process of regulated exocytosis has received considerable interest as a key component of synaptic transmission. Fusion of presynaptic vesicles and the subsequent release of their neurotransmitter contents is driven by a series of interactions between evolutionarily conserved proteins. Key insights into the molecular mechanisms of vesicle fusion have come from research using genetic model systems such as the nematode worm Caenorhabditis elegans. We review here the current knowledge regarding regulated exocytosis at the C. elegans synapse and future research directions involving this model organism. (C) 2012 Elsevier Ltd. All rights reserved.
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