期刊
CELL CALCIUM
卷 50, 期 2, 页码 157-167出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2011.03.011
关键词
NAADP; Two-pore channels; TPC1; TPC2; TPCN1; TPCN2; Calcium; Endosomes; Lysosomes; Acidic calcium stores
类别
资金
- BBSRC
- Wellcome Trust
- BBSRC [BB/G013721/1, BB/H009736/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G013721/1, BB/H009736/1] Funding Source: researchfish
Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca2+ that is tapped by the Ca2+-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca2+ release from this acidic Ca2+ store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family. (C) 2011 Elsevier Ltd. All rights reserved.
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