期刊
CELL CALCIUM
卷 47, 期 2, 页码 103-111出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2009.12.007
关键词
Lysosomal storage diseases; Calcium; Autophagy; Mitochondria; Signaling; Lysosomes; Ion channels; Mucolipins; Two pore channels; TRPML1; TRPML3; Cell death
类别
资金
- National Institutes of Health [HD058577, ES016782, DE12309, DK38938]
- Ruth S. Harrell Professorship in Medical Research
- Uehara Memorial Foundation, Tokyo, Japan
Lysosomal storage diseases (LSDs) are caused by inability of cells to process the material captured during endocytosis. While they are essentially diseases of cellular indigestion, LSDs affect large number of cellular activities and, as such, they teach us about the integrative function of the cell, as well as about the gaps ill our knowledge of the endocytic pathway and membrane transport. The present review summarizes recent findings on Ca2+ handling in LSDs and attempts to identify the key questions on alterations in Ca2+ signaling and membrane transport in this group of diseases, answers to which may lie in delineating the cellular pathogeneses of LSDs. (C) 2009 Elsevier Ltd. All rights reserved.
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