期刊
CELL CALCIUM
卷 48, 期 6, 页码 315-323出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2010.09.005
关键词
Inositol 1 4 5-trisphosphate receptor; Calcium signaling; Colorectal cancer; Prognosis; Apoptosis
类别
资金
- Ministry of Education Culture Sports Science and Technology Japan [20591583, 20591598, 18591490]
- NIH [DK57751, DK45710, DK34989, DK61747]
- YCCI [ULRR024139, DK082600]
- Grants-in-Aid for Scientific Research [20591583, 20591598, 18591490] Funding Source: KAKEN
The inositol 1 4 5-trisphosphate receptor (InsP3R) mediates Ca2+ signaling in epithelia and regulates cellular functions such as secretion apoptosis and cell proliferation Loss of one or more InsP3R isoform has been implicated in disease processes such as cholestasis Here we examined whether gain of expression of InsP3R isoforms also may be associated with development of disease Expression of all three InsP3R isoforms was evaluated in tissue from colorectal carcinomas surgically resected from 116 patients Type I and II InsP3Rs were seen in both normal colorectal mucosa and colorectal cancer while type III InsP3R was observed only in colorectal cancer Type III InsP3R expression in the advancing margins of tumors correlated with depth of invasion lymph node metastasis liver metastasis and TNM stage Heavier expression of type III InsP3R also was associated with decreased 5-year survival shRNA knockdown of type III InsP3R in CACO-2 colon cancer cells enhanced apoptosis while over-expression of the receptor decreased apoptosis Thus type III InsP3R becomes expressed in colon cancer and its expression level is directly related to aggressiveness of the tumor which may reflect inhibition of apoptosis by the receptor These findings suggest a previously unrecognized role for Ca2+ signaling via this InsP3R isoform in colon cancer (C) 2010 Published by Elsevier Ltd
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