期刊
CELL BIOLOGY INTERNATIONAL
卷 38, 期 11, 页码 1337-1343出版社
WILEY
DOI: 10.1002/cbin.10320
关键词
autophagy; MSCs; mTOR; neuronal differentiation
类别
资金
- National Natural Science Foundation of China [81071114]
Autophagy is involved in cell differentiation. We present evidence that autophagy is activated during -mercaptoethanol (-ME)-induced neuronal differentiation of bone marrow mesenchymal stem cells (MSCs), in which mammalian target of rapamycin (mTOR) signaling is important. mTOR activity declined after being transported from the nucleus to the cytoplasm. Using 3-methyladenine (3-MA) and rapamycin to regulate the activity of mTOR, it was found that the efficiency of neuronal differentiation was affected.
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