期刊
CELL BIOLOGY INTERNATIONAL
卷 39, 期 1, 页码 3-22出版社
WILEY
DOI: 10.1002/cbin.10345
关键词
inflammation-associated diseases; polyunsaturated fatty acids; resolvin; resolution
类别
资金
- Shanghai Postdoctoral Scientific Program [12R21416100]
Resolution is an active process that terminates inflammatory response to maintain health. Acute inflammation and its timely resolution are important in host response to danger signals. Unresolved inflammation is associated with widely recurrent diseases. Resolvins, including the D and E series, are endogenous lipid mediators generated during the resolution phase of acute of inflammation from the -3 PUFAs, DHA, and EPA. They have anti-inflammatory and pro-resolving properties that have been determined in many inflammation studies in animal models. In this review, we provide an updated overview of biosynthesis, actions, and signaling pathways of resolvins, thereby underscoring their diverse protective roles and introducing novel therapeutic strategies for inflammation-associated diseases.
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