期刊
CELL BIOLOGY INTERNATIONAL
卷 37, 期 5, 页码 430-435出版社
WILEY
DOI: 10.1002/cbin.10046
关键词
apoptosis; endothelial progenitor cells; pioglitazone; PI3K/AKt
类别
资金
- Science and Technique Foundation of the Science & Technology Department of Henan Province
Selective peroxisome proliferator-activated receptor- (PPAR-) agonist affects the functions of endothelial progenitor cells (EPCs). This study explores the effect of selective PPAR- agonist, pioglitazone, on EPC apoptosis. The cells were cultured and identified via the double staining method in a medium containing different concentrations of pioglitazone. EPC apoptosis was detected by flow cytometry. On Day 7, EPCs engulfed DiL-ac-LDL and FITC-UEA-1, and showed yellow fluorescence in a laser-scanning confocal microscope. EPC apoptosis inhibition was maximal at 50 mu mol/L. The ability of pioglitazone to prevent EPC apoptosis may be mediated by the PI3K/Akt signal pathway. The use of thiazolidine two ketone (TZD) to reduce EPC apoptosis may have some potential in treating vascular diseases.
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