期刊
WATER SCIENCE AND TECHNOLOGY
卷 47, 期 2, 页码 181-188出版社
I W A PUBLISHING
DOI: 10.2166/wst.2003.0115
关键词
early warning systems; genotoxicity; HPLC; LC-MS/MS; monitoring strategy; organic micropollutants
Two novel water quality monitoring concepts were developed: the HPLC-fingerprint for the monitoring of yet unidentified pollutants and the HPLC-Toxprint(R) for the recognition of (unknown) toxic or genotoxic compounds. The paper describes applications of both concepts. The HPLC-fingerprint is used for the evaluation of the overall water quality in addition to the monitoring of individual pollutants. Based on their occurrence (frequency, concentration, location) a listing of unknown priority pollutants is set up. Participating waterworks monitor for these compounds using a dedicated HPLC-DAD library that contains the required compound data (UV-absorbance spectrum, retention time index). In five years of experience with this concept, the HPLC-fingerprint was also found very suitable for the retrieval of new priority pollutants in existing HPLC-fingerprint databases, providing historic data on these new compounds. The HPLC-fingerprint concept was also used as an Early Warning System for accidental spills or sabotage. The HPLC-Toxprint was successfully applied in identifying genotoxicity (in the umu-test) in various waste water samples. By the application of LC-MS/MS genotoxicity could be assigned to acridine-derivatives in one of these wastewaters. To enable the evaluation of drinking water resources; the sensitivity of the HPLC-Toxprint was improved, now allowing the detection of pollutants with a 10% genotoxic potential as compared to 2-aminoanthracene (the positive control compound) at concentrations as low as 0.1 mug/l.
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